Zoloft Erectile Dysfunction Permanent


Zoloft is an antidepressant drug in the category of selective serotonin reuptake inhibitor (SSRI). It is prescribed to treat depression and other psychological issues like anxiety etc.  There are concerns that this drug can also lead to erectile dysfunction in males.

Erectile dysfunction is weakness in erection in males that makes it difficult to get an erection and sustain the erection for the completion of the intimate session. Males often are prescribed antidepressant drugs to treat depression induced erectile dysfunction. However, the side- effects of some of the drugs prescribed in the SSRI category also create erectile difficulties.

Role of antidepressant drugs in curing depression

Brain sends messages and information through neurotransmitters, which act as chemical messengers.  When there is some issue with the neurotransmitters, the brain cannot send or receive signals. There may not be enough or there are enough neurotransmitters.  Our brain is not able to use the neurotransmitters sufficiently.  The main problem is lack of regulation in working of neurotransmitters. Antidepressant drugs change the function of neurotransmitters so that messages and signals are properly transmitted through the brain to the central nervous system for the erection process in case of depression induced erectile dysfunction. When the brain is able to receive and process signals clearly, the depression symptoms go away.

Role of Zoloft in erectile dysfunction

Zoloft enhances the function of chemical messengers in brain by increasing amount of serotonin.  Increase in levels of serotonin lowers symptoms of anxiety and depression, but its side effect also includes erectile difficulties in males. It has been estimated that this drug reduces sensitivity in sexual organs, or reduces the desire level. Experts feel that by reducing the action of dopamine and nor-epinephrine, two neurotransmitters, the desire levels are adversely affected. Males also find it difficult to get aroused.

When a male is not sufficiently aroused, the chances of erection also go down. The erection happens with arousal, which triggers the flow of blood in the pelvic area. The flow of blood in the male organ leads to an erection with stimulation. So any drop in arousal level directly impacts the erection process.

Third way, Zoloft causes erectile dysfunction through blocking action of nitric oxide. Nitric oxide is stimulated during the arousal stage. It dilates the blood vessels to facilitate greater flow to the male organ. When doctors prescribe Levitra 40 mg, it blocks the action of PDE5 enzyme to allow free hand to nitric oxide to work and create conditions for free flow of blood. Thus by blocking the action of nitric oxide, the major obstacle is created in the erection process.

The impact of Zoloft on male erection process is not the same for all males.  Any side effect that curbs the erection process is temporary. Sometimes the body after adjustment gets back to the normal erection level.

All antidepressant drugs do not cause erectile dysfunction

Mention the erection difficulties to the doctor if you feel that Zoloft is causing some erection issues.  There are other medicines in the same category that show no adverse impact on the erection process. The same lower dose may also reduce the severity of erection problems. Or other drugs can be prescribed by the doctor. There is no harm in trying other medication within the same category to come to the right combination of medicines for curing erectile dysfunction.

In fact, the drug in question, Zoloft is considered less likely to produce erectile dysfunction as side effects according to the online medical team of thesynergycomapnies.com.  The sertraline, which is an active ingredient in this drug, has less adverse impact on the erection process.

Also you have to consider the fact that depression induced erectile dysfunction goes away only when depression is cured through medication. And some erectile difficulties during the medication can be cured by Sildenafil citrate 150 mg after medical consultations. There is no need to stop medication, as chances of relapse of depression related symptoms remain high.

Understand the timing of erection issue

Understand how long it takes to face erection difficulties after using Zoloft. If it happens only after Zoloft, you can fix the timing for an intimate session before the use of medicine.  Also after stopping the medicines, it takes time to see decline in side effects related to erection issues.


There are chances of change in the erection process after using Zoloft as an antidepressant drug. However, the side effects are not permanent and one can use another drug without side effects on erection. Without consultation never stop a medicine, as the relapse of depression remains a possibility.


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